Acute Subdural Hematoma
Conditions
Interventions
Preoperatively rapid-induced hypothermia therapy
Normothermia
Sponsors
Department of Emergency and Critical Care Medicine Graduated School of Medicine, Nippon Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Non-penetrating traumatic brain injury 2. GCS motor score <= 5 (not following commands) 3. Estimated or known age 21-65 years 4. Acute subdural hematoma requiring emergent craniotomy within 6 hours of initial injury
Exclusion criteria
Exclusion criteria: 1.Total GCS3 and bilateral fixed and dilated pupils 2.Following commands after an initial period of coma (GCS motor score of 6) 3.Known pre-existing neurological deficit (previous TBI, stroke) 4.Concomitant spinal cord injury 5.Arrival temperature is <35C 6.Hemodynamic instability (MAP<60mmHg for 30 minutes) 7.Active cardiac dysrhythmia resulting in hemodynamic instability 8.Pregnancy 9.Duret hemorrhage 10.Prisoner or Ward of the State 11.Known history of clotting disorder (heparin induced thrombocytopenia, PE/DVT) 12.Injury to other body organ where hypothermia would be precluded because of bleeding risk (e.g., grade 3 liver laceration; bowel laceration; flail lung or INR>1.4) 13.Inability to obtain informed consent or utilize exception to informed consent for emer-gency research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparing the ratio of good and poor outcome based on 6-month Glasgow Coma Scale Extended(GOSE) | — |
Countries
Japan,North America
Contacts
Public ContactShoji Yokobori
Graduated School of Medicine, Nippon Medical School Department of Emergency and Critical Care Medicine
Outcome results
None listed