hepatocellular carcinoma cases require hepatectomy
Conditions
Interventions
Branched-chain amino acid granules(BCAA, Livact) is orally administered three times a day for 2 weeks prior to hepatectomy and 1 month after hepatectomy(hypoalbuminemia group).
No administration of BC
Sponsors
Keio University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)hepatocellular carcinoma(including combined hepatocellular and cholangiocarcinoma) by preoperative imaging examination 2)planned hepatectomy 3)ECOG Performance Status 0 to 2 4)appropriate liver function for hepatectomy according to the results of the Child-Pugh classification and the ICG-R15 test (within 30 days before the registration) 5)written informed consent
Exclusion criteria
Exclusion criteria: 1)severe diabetes, or suspected abnormal sugar metabolism because of high dosage of steroids 2)abnormal amino acid metabolism 3)history of hypersensitivity against Livact 4)pregnant or willing to get pregnant 5)patien's offer discontinuation of the study 6)doctor's decision not to be registered to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative improvement of liver function | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative course liver regeneration rate | — |
Countries
Japan
Contacts
Public ContactHiroshi Yagi
Department of surgery, Keio University, school of medicine Department of Surgery
Outcome results
None listed