Immune improvement by antiretroviral therapy in HIV-1 infected children

Immune improvement by antiretroviral therapy in HIV-1 infected children - Immune improvement by ART in HIV-infected children

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000014809

Enrollment

100

Registered

2014-08-25

Start date

2014-08-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Human immunodeficiency virus type 1 (HIV-1) infection

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) HIV(+) ART(-): children who will start ART for the first time in their life. (2) HIV(-): HIV-negative children whose age and gender matched with subject (1)

Exclusion criteria

Exclusion criteria: The children whose consent is not obtained

Design outcomes

Primary

Measure	Time frame
Activation and differentiation of CD4+ and CD8+ cells and the proportion of different CD4+ cell subsets such as Th1/Th2/Th17/Treg (regulatory T cells), proportion of MAIT cells	—

Secondary

Measure	Time frame
(1) HIV-1 viral load (VL) (2) CD4+ cell count (3) SNPs related to therapeutic outcomes of ART (4) Concentration of sCD14	—

Countries

Asia(except Japan)

Contacts

Public ContactXiuqiong Bi

Graduate school of Medicine, Kanazawa University Department of Viral infection and International Health

bixiuqio@staff.kanazawa-u.ac.jp+81-76-265-2229

Outcome results