Type A Acute Aortic Intramural Hematoma
Conditions
Interventions
60bpm using beta-blocker
Heart rate control to 60-80 bpm using beta-blocker
Sponsors
Saiseikai Kumamoto Hospital Intensive Care Unit
Saiseikai Matsuyama Hospital Saiseikai Futsukaichi Hospital Saiseikai Omuta Hospital Saiseikai Yokohamashi Tobu Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)The admitted patient with type A acute aortic intramural hematoma within two days after the onset 2)The patient that the agreement by the sentence is provided having ability for agreement
Exclusion criteria
Exclusion criteria: 1)Cardiac tamponade, Organ ischemia, >50mm in maximum aortic diameter,ulcer like projection in the ascending aorta 2)Contraindications of beta-blocker including bronchial asthama 3)Marfan syndrome 4)Shock vital including < 100mmHg in systolic blood pressure 5)The less than one year in survival prognosis due to malignancy et al 6)The participation in this study is not appropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival rate and Aortic event:aortic rupture, The progression of aneurysm(>5mm/6 months), The requirement of surgical intervention including stent-grafting. These events will be determined to be based on the CT findings at admission, 1 week and 2 weeks after the admission, 1 month, 3 months, 6 months, 1 year, 1.5 years, 2 years after the discharge, and the occurence of aortic symptom. | — |
Secondary
| Measure | Time frame |
|---|---|
| The expansion rate of aortic diameter, The length of intensive care unit stay, The length of hospital stay, The agitation and delirium(scalling score), Hypoxia, (PaO2/FiO2 ratio), Acute kidney injury, The length of the required intra-venous anti-hypertensive medicine, sedative score. Blood chemical examination: the count of white blood cell, red blood cell, and platelet, hemoglobin, hematocrit,prothrombin time, activated partial thromboplastin time, fibrinogen, fibrinogen degradation products, plasmin-alpha2 plasmin inhibitor complex, thrombin-antithorombin complex, D-dimmer, antithrombin three, total protein, albumin, total bilirubin, aspartate aminotransferase, alanine aminotransferase, gammma-glutamyl transpeptidase, lactate dehydrogenase, alkaline phosphatase, creatine phosphokinase, uric acid, blood urea nitrogen, creatinine, serum sodium, serum potassium, serum chloride, C-reactive protein, brain natriuretic peptide, catecholamine 3 fractionation, plasma renin activity,transforming growth factor-beta. | — |
Countries
Japan
Contacts
Public ContactTakashi Unoki
Saiseikai Kumamoto Hospital Intensive Care Unit
Outcome results
None listed