Severe neutropenic patients following alloHSCT or chemotherapy
Conditions
Interventions
Granulocyte transfusion
Sponsors
Kansai Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Recipient: Severe neutropenia, recovery is not expected within five days, severe infection with elevated CRP level or active focus to be fatal infection, written informed consent. Donor: Relative within fourth degree, 20 to 54 years, compatible ABO blood type or minor incompatible, healthy donor, written informed consent.
Exclusion criteria
Exclusion criteria: Recipient: not expected to survive more than 30 days, self hematopoiesis is not expected to recover within 30 days. Donor: allergy aginst G-CSF, pregnant or possible to be pregnant, breast feeding, history of thrombosisi or have risk of thrombosis, splenomegaly, comorbidiy or history of interstitial pneumonia, history of cancer, comorbidities of cardiac, pulmonary, renal diseases to be treated, comorbidities of inflammatory, autoimmune diseases to be treated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate safety and efficacy in both donor and recipient | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival in recipient at 30 days after granulocyte transfusion | — |
Countries
Japan
Contacts
Public ContactShinya Fujita
Kansai Medical University First Department of Internal Medicine
Outcome results
None listed