Comparison of endothelial function with the mandibular advancement device (MAD) versus continuous positive airway pressure (CPAP) among patients with moderate sleep apnea syndrome: multicenter, open label, prospective randomized non-inferiority crossover trial

Comparison of endothelial function with the mandibular advancement device (MAD) versus continuous positive airway pressure (CPAP) among patients with moderate sleep apnea syndrome: multicenter, open label, prospective randomized non-inferiority crossover trial - Comparison of endothelial function with the mandibular advancement device (MAD) versus continuous positive airway pressure (CPAP) among patients with moderate sleep apnea syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000014723

Enrollment

Registered

2014-08-01

Start date

2013-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep apnea syndrome

Interventions

treat with CPAP then treat with MAD treat with MAD then treat with CPAP

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1: >20 years of age 2: 20<AHI<=40 by full polysomnography study 3: With two criteria for OSAS symptoms 4: With postural dependency defined as (AHI of supine position > 2 times AHI during sleeping position other than supine)

Exclusion criteria

Exclusion criteria: 1. History of treatment of OSAS 2. Patients who needs to treat immediately 3. With central sleep apnea dominance (CAHI>5) 4. With insomnia or hypersomnia not relate to OSAS 5. Using sedatives, 6. With pulmonary (asthma, COPD etc.) or mental disease which needs to treat 7. Unable to fit MAD 8. With coronary heart disease and cerebrovascular disease 9. On hemodialysis 10. Patients who are judged unsuitable to participate in the study by the attending physician

Design outcomes

Primary

Measure	Time frame
The degree of change in FMD at the end of each course of therapy	—

Countries

Japan

Contacts

Public ContactShin-ichi Ando

Kyushu university hospital Sleep Apnea Center

shinando@sleep.med.kyushu-u.ac.jp093-642-5987

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026