malignant glioma
Conditions
Interventions
None listed
Sponsors
Department of Neurosurgery Ehime University Graduated School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Histologically confirmed malignant glioma 2)18 Years and older 3)Karnofsky performance status >/= 50% 4)no previous chemotherapy and radiotherapy 5)Patients who have undergone recent therapy recurrent or progressive tumor are eligible provided that a minimum of 28 days must have elapsed from the day of prior therapy 6)To have a proper organ function 7)Under the management responsibility of the study (sharing) doctor, contraception during the study is possible regardless of gender. 8)Laboratory values ​​that were carried out before registration began meet one of the following criteria:. Clinical test item standard Neutrophil count (real) >/= 1,500 / mm3 Platelet count >/= 100,000 / mm3 Serum creatinine 1.5mg/dL or less
Exclusion criteria
Exclusion criteria: 1)Patients with a history of hypersensitivity to dacarbazine or temozolomide. 2)Patients who are contraindicated to chemotherapeutic agents other than temozolomide. 3)The patient in need of surgery, additional radiotherapy to the PD after determination 4)Pregnant or lactating women 5)Double cancer of activity 6)It is complicated by pneumonia or meningitis in need of treatment. 7)Has been complicated by psychiatric symptoms or psychosis, it is determined that participation in the research is difficult. 8)patients have been complicated by uncontrolled diabetes. 9)patients have unstable angina or a history of myocardial infarction within 3 months. 10)And has a history of interstitial pneumonia or pulmonary fibrosis,. 11)When used interferon beta preparation maintenance therapy by temozolomide, patients corresponding to the following items are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)KPS, 2)survival time from PD, 3)adverse event | — |
Countries
Japan
Contacts
Public ContactShohei Kohono
Ehime University Graduated School of Medicine neurosurgery
Outcome results
None listed