Patients with chronic heart failure
Conditions
Interventions
Sponsors
Division of cardiology, Kobe university hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 Patients between 20 and 80 years old 2 Out patients and inpatients with chronic heart failure 3Patients with hemodynamically stable condition with standard heart failure treatment including beta blocker, ACE inhibitor, ARB, and diuretics. 4 Patients who can tolerate 5 minutes of leg positive pressure stress echocardiography. 5 Patients with symptom of heart failure, or those with previous admission due to heart failure. 6 Patients with written informed consent. 7 Patients whose medication will not significantly change during 2 years study period.
Exclusion criteria
Exclusion criteria: 1) Patients with significant hypotension (<90/50mmHg) or uncontrolled hypertension (>160/90mmHg). 2) Patients with acute illness within 3 months. 3) Patients with life-threatening ventricular arrhythmia. 4) Patients with NYHA 4 heart failure. 5) Patients with severe hepatic diseases including fulminant hepatitis, liver cirrhosis, or hepatic tumor. 6) Patients with severe renal diseased or those with hemodialysis. 7) Patients who experienced malignancy within 5 years. 8) Pregnant women. 9) Patients with venous thrombosis or the history of venous thrombosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Combined endpoint of admission due to heart failure, death from heart failure, and sudden cardiac death | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Change in NYHA functional class from baseline 2) Changes in left ventricular ejection fraction, left ventricular end-diastolic, and end-systolic volume from baseline 3) Changes in right ventricular and left atrial function from baseline using speckle-tracking echocardiography | — |
Countries
Japan
Contacts
Public ContactKensuke Matsumoto
Kobe university hospital Division of cardiology
Outcome results
None listed