oral squamous cell carcinoma
Conditions
Interventions
Induction chemotherapy Cetuximab day1(400mg/m2), day 8 (250mg/m2) S-1 day 1-14 (80mg/m2) CDDP day 1-5,8-12 (5mg/m2)
Sponsors
The workshop of chemotherapy for oral cancer
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) histologically confirmed SCC 2) measurable and evaluable tumor 3) untreated case with more than large T2 (maximum size >3cm) tumor 4) Performance status 0-1 5) The functions of main organ (bone marrow, heart, lung, liver, kidney) are almost normal.
Exclusion criteria
Exclusion criteria: 1) double cancer case 2) severe systemic complications 3) metastasis to CNS 4) ischemic heart disease 5) active gastrointestinal ulcer 6) severe mental disorder 7) women who are fertile or during pregnancy 8) past illness of severe drug allergy 9) attending doctor's decision as unsuitable patient for this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| histological effect (histological response rate) | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival, disease-free survival, complication after surgery, the rate of avoidance of reconstructive surgery | — |
Countries
Japan
Contacts
Public ContactMitsuhiro Nakazawa
Osaka university dental hospital 2nd dept. of oral & maxillofacial surgery
Outcome results
None listed