The elderly patient who undergoes total knee arthroplasty(TKA)
Conditions
Interventions
Administration of 200 mg minocycline per day from 1 day before to 7 days after surgery
Administration of a placebo(sugar) from 1 day before to 7 days after surgery
Sponsors
Gunma University Hospital, Department of Anesthesiology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) The patient who has a score of 15 or more in MoCA-J test 2) The patient with PS1 or PS2 3) The patient gave written informed consent
Exclusion criteria
Exclusion criteria: 1)The patient with the mental disease 2)The patient with the drug dependency or alcoholism 3)The patient with cardiac disease 4)The patient with hepatic disease 5)The patient with renal disease 6)The patient with allergy to tetracycline including minocycline 7)The patient taking calcium, magnesium, aluminum, lantern, iron medicine, anticoagulant,sulfonylurea-based hypoglycemic drug, methotrexate, porfimer sodium, digoxin,oral contraceptive, vitamine A 8)The patient to whom a doctor judged inappropriate for participating in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We are going to evaluate the cognitive function 1 week and 3 months after the surgery to test whether minocycline can decrease the incidence of POCD. | — |
Secondary
| Measure | Time frame |
|---|---|
| We are going to compare the incident rate of delirium between minocycline and placebo group within 1 week after surgery. | — |
Countries
Japan
Contacts
Public ContactTomonori TAKAZAWA
Gunma University Hospital Department of Anesthesiology
Outcome results
None listed