Infertility treated by ICSI for severe male infertility or fertilization failure due to oocyte problem.
Conditions
Interventions
Subjects can freely decide to participate in the trial or not, and do not have any disadvantages when they do not participate. Informed consents are obtained from all participants after they have rece
Sponsors
Women's Clinic Jinno
Kitazato Corporation
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: The study include patients who satisfy all the following criteria; (1) age = or < 39 years, (2) to undergo the first, second or third attempt of assisted reproductive technology (ART) therapy, (3) the number of retrieved oocytes are > or = 6, and (4) mainly severe male infertility (or infertility possibly due to anti-sperm antibody, hyperproduction of reactive oxygen species by sperm, or fertilization failure from oocyte factors).
Exclusion criteria
Exclusion criteria: Patients are excluded when they meet any of the following criteria; (1) diminished ovarian reserve (AMH < 2 ng/mL, day 3 FSH > 15 IU/L, or day 3 estradiol > 60 pg/mL, (2) non-obstructive azoospermia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of embryonic development per injected oocyte. | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of sticks until successful injection, the rate of survived oocyte per injected oocyte, and fertilization rate. | — |
Countries
Japan
Contacts
Public ContactMasao Jinno
Women's Clinic Jinno Reproductive Medicine
Outcome results
None listed