Study of the effect of Proton Pump Inhibitor (PPI) on intra-gastric pH in healthy volunteer - Comparison of Esomeprazole and Rabeprazole -

Study of the effect of Proton Pump Inhibitor (PPI) on intra-gastric pH in healthy volunteer - Comparison of Esomeprazole and Rabeprazole - - Study of the effect of Proton Pump Inhibitor (PPI) on intra-gastric pH in healthy volunteer - Comparison of Esomeprazole and Rabeprazole -

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000014577

Enrollment

Registered

2014-07-16

Start date

2014-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux disease(GERD)

Interventions

Placebo once daily(7days)-wash out 7days over-Esomeprazole20mg once daily after breakfast(7days)-wash out 7days over-Esomeprazole20mg once daily before breakfast(7days) 7days over-Rabeprazole10mg once

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.healthy adults 2.without upper abdominal symptom 3.without Helicobacter pylori

Exclusion criteria

Exclusion criteria: 1.with taking drugs affecting gastrointestinal motor function 2.with a history gastrectomy 3.complicated with severe cardiac, hematologic, renal, hepatic diseases or malignant tumor 4.possibility to be pregnant or pregnant women 5.subjects who are not eligible for participation judged by a doctor

Design outcomes

Primary

Measure	Time frame
evaluation of intra-gastric pH following single oral pre- and postprandial administrations of esomeprazole and rabeprazole on 7th day	—

Countries

Japan

Contacts

Public ContactKenji Furuta

Shimane University Faculty of Medicine Department of Gastroenterology

kfuruta@med.shimane-u.ac.jp0853-20-2190

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026