The effect of thrombomodulin-alpha on the systemic inflammation and the postoperative course among patients after open heart surgery for the congenital heart diseases.

The effect of thrombomodulin-alpha on the systemic inflammation and the postoperative course among patients after open heart surgery for the congenital heart diseases. - The induction of thrombomodulin-alpha for patients with open heart surgery for congenital heart diseases.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000014504

Enrollment

Registered

2014-07-08

Start date

2013-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congenital heart diseases

Interventions

Administration of thrombomodulin-alpha Placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Infants and neonates with congenital heart diseases who are scheduled to undergo open heart surgery with the aortic cross clamp over 1 hour.

Exclusion criteria

Exclusion criteria: Patients with chromosomal abnormalities. Cases with other investigational medicine.

Design outcomes

Primary

Measure	Time frame
adverse events	—

Secondary

Measure	Time frame
Clinical efficacy of the therapy in postoperative period.	—

Countries

Japan

Contacts

Public ContactTakeshi Yoshii

Gunma Children's Medical Center Dept. of Cardiovascular Surgery

yosiit-tky@umin.net0279-52-3551

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026