Breast Cancer
Conditions
Interventions
None listed
Sponsors
Juntendo University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: A patient planning to undergo breast biopsy with written informed consent because breast cancer was clinically suspected 1. Lesion over 2 cm tumor size 2. Age >= 20 and < 75 3. Performance status 0-1 4. Normal cardiac function (EF>55% by ultrasound) 5. Normal liver functions (AST/ALT <= upper limit of normal * 2.5 and T.bil <= 2.0mg/dl) 6. Normal kidney function(Cr <= 1.5mg/dl) 7. Without distant metastatic lesions, basically, except the for stage IV without lethal metastases, and scheduled to undergo local control surgery after chemotherapy Patients with neoadjuvant chemotherapy are as follows: (1) Fine needle aspiration cytology for axillary lymph nodes proven to be positive for cancer cells or axillary lymph node positivity is highly suspected clinically (2) Breast conserving operation is expected with neoadjuvant chemotherapy, regardless of nodal status (3) Triple negative or HER 2 type breast cancer according to core needle biopsy results, regardless of nodal status (4) Judged to have an indication for PST by the doctor in charge
Exclusion criteria
Exclusion criteria: 1. Ductal carcinoma in situ 2. Any past history of malignant disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare RNA expressions between breast cancers with complete response to neoadjuvant chemotherapy and tumors with non-complete responses for each subtype | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare RNA expressions in each breast cancer subtype | — |
Countries
Japan
Contacts
Public ContactHyonmi Sai
Juntendo University Breast Oncology
Outcome results
None listed