hepatocellular carcinoma or colorectal liver metastases
Conditions
Interventions
application of Seprafilm after hepatectomy for the treatment of hepatocellular carcinoma or metastatic liver tumors. No application of Seprafilm after hepatectomy for the treatment of hepatocellular
Sponsors
Department of Digestive Surgery, Nihon University School of Medicine
Hepato-biliary-pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Age over 20 years old at the registration day. 2) ECOG Performance Status is 0-2. 3) Patients with liver damage A or B 4) Patients with primary or secondary hepatectomy scheduled for hepatocellular carcinoma diagnosed by CT imaging 5) Patients with primary or secondary hepatectomy scheduled for the treatment of colorectal liver metastases in our department. 6) The history of prior local therapy are permitted if liver tumor are resectable. 7) Patients have enough organ function for study treatment within 14 days before registration. - neutrophil count: >=2,000/mm3, <=10,000 /mm3 - platelet: >=50,000/mm3 - serum bilirubib level: <=1.5mg/dL - PT(%): >=50% - serum creatinine level: <=1.5mg/dL - AST: <=100IU/L - ALT: <=100IU/L - albumin: >=3.0g/dL 8) Written informed consent
Exclusion criteria
Exclusion criteria: 1) Severe comorbidity 2) Severe infectious disease 3) Pleural effusion, ascites fluid and the pericardial fluid needing treatment 4) Patients with other primary malignancies. 5) A past history of drug allergy (needs continuation therapy) 6) Chronic systemic treatment of corticosteroid 7) Bleeding tendency, coagulation disorder, abnormality of coagulation factor, or administered anticoagulant 8) Patients infected with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). 9) Patients during pregnancy, breast- feeding, or at risk of becoming pregnant. 10) Psychological disorder 11) Considered not appropriate for surgery 12) Patients considered inappropriate by the study investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| adhesion time needed for dissecting the adhesions in reoperation of the liver in future | — |
Countries
Japan
Contacts
Public ContactKanamoto Akira
Nihon University School of Medicine Department of Digestive Surgery
Outcome results
None listed