Hypertension
Conditions
Interventions
One group taken the combination ARB with diuretics (Ecard HD(R))
One group taken the combination ARB with diuretics (Unisia HD(R))
Sponsors
Jichi Medical University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with diagnosed hypertension in our hospital and collaborate research institutes. (Inclusion criteria) 1)Patients taken each calcium blocker or ARB, or patients with alfa blocker or beta blocker adding in each calcium blocker or ARB. 2)In spite of performing life modification (diet and exercise) and the above medication, their clinic BP is above 140/90mmHg.
Exclusion criteria
Exclusion criteria: (Exclusion criteria) 1)Allergy of these drugs in this study 2)Anuria or hemodialysis 3)Acute renal failure 4)Significant low sodium and potassium 5)Pregnancy or possibility of pregnancy 6)Not given informed consent (adolescents, dementia) 7)In case the physicians decide to be inappropriate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -change in blood pressure at home blood pressure measurement -change in augmentation index | — |
Secondary
| Measure | Time frame |
|---|---|
| -change in blood pressure (BP) at 24hr BP monitoring and clinic BP -change in NTproBNP, hsCRP, hsTnT, cystatin C, VEGF-C, LDL cholesterol, triglyceride, HDL cholesterol, BUN, creatinine, potassium, sodium, glucose, urine-sodium, and urinary albumin creatinine ratio | — |
Countries
Japan
Contacts
Public ContactSatoshi Hoshide
Jichi Medical University School of Medicine Division of Cardiovascular Medicine, Department of Medicine
Outcome results
None listed