Advanced gastric cancer
Conditions
Interventions
Neoadjuvant chemotherapy TS-1: 80mg/m2 Day 1-14 CDDP: 20mg/m2 Day 1, 15 Paclitaxel: 100mg/m2 Day 1, 15 Surgery should be performed after 2 courses of neoadjuvant chemotherapy.
Sponsors
School of Medicine, Keio University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) adenocarcinoma of the stomach 2) Macroscopically either large Type 3 (more than 8cm)or 4 3) Without neither liver nor pritoneal metastasis 4) The invasion to esophagus is within 3cm. 5) Age: From 20y.o to 75 y.o. 6) ECOG PS 0 or 1 7) No prior treatment 8) Possible oral intake 9) Sufficient function of important organs 10) written informed consent
Exclusion criteria
Exclusion criteria: 1) with severe drug allergy 2) with highly lymph node metastases 3) with severe infection 4) with severe diarrhea 5) with severeintestinal paralysis or ileus 6) with interstitial pneumonia or pulmonary fibrosis with other active malignant disease 7) with active other malignancy 8) with severe diabetes 9 ) with severe heart disease 10) pregnant or nursing women or women who like be pregnant and willing to get pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2-year overall survival | — |
Countries
Japan
Contacts
Public ContactTsunehiro Takahashi
School of Medicine, Keio University Department of Surgery
Outcome results
None listed