Chronic Obstructive Pulmonary Disease (COPD)
Conditions
Interventions
glycopirronium inhalation therapy
Sponsors
Department of Respiratory Medicine, Osaka Police Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 40 years-old or older 2. A history of cigarette smoking or excessive exposure to smoke. 3. Clinically stable moderate-to-severe COPD, according to the Global Initiative on Obstructive Lung Disease (GOLD) staging. 4. Never treated with long-acting beta-agonists (LABA) or more than 4 weeks after last LABA inhalation. 5. Never treated with long-acting muscarinic antagonists (LAMA) or more than 4 weeks after last LAMA inhalation. 6. Able to walk independently or with a cane. 7. Sufficient cognitive function to follow the instructions for using the pulse oximetry equipment and accelerometers. 8. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactation women, or women with known or suspected pregnancy and men who want let to pregnancy 2. Closed angle glaucoma 3. Severe urination disorder 4. A history of hypersensitivity reaction against glycopirronium 5. A recent history of respiratory infection and acute exacerbation in the previous one month. 6. Clinically severe athma. 7. Other significant cardiac diseases or medical problems precluding ambulatory activity at hom 8. Physician's decision.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of activity intensity of 1 or more, accessed by accelerometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Pulmonary functions; FVC, FEV1,FEV1%, V50, V25 2. QOL and activity ; CAT, SF-36, modified MRC 3. Physical activity; calorie consumption, steps, amount of exercise 4. Arterial blood test; PaO2, PaCO2 5. Exacerbation episode | — |
Countries
Japan
Contacts
Public ContactSeigo Minami
Osaka Police Hospital Department of Respiratory Medicine
Outcome results
None listed