The effects of brain insulin signaling and exercise on incretin secretion, gastric emptying and appetite.

The effects of brain insulin signaling and exercise on incretin secretion, gastric emptying and appetite. - The effects of brain insulin signaling and exercise on incretin secretion, gastric emptying and appetite.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000014153

Enrollment

Registered

2014-06-16

Start date

2014-06-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes obesity

Interventions

intranasal insulin administration intranasal placebo (normal saline solution) administration a bout of exercise no exercise

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: healthy adults

Exclusion criteria

Exclusion criteria: subjects with arrhythmia, ischemic heart disease, chronic heart failure, hypertension (BP is 140mmHg or over in systolic, or 90mmHg or over in diastolic), diabetes, or obesity (BMI is 30 or more) subjects who are judged by a doctor to be inappropriate for participating in the exercise test

Design outcomes

Primary

Measure	Time frame
plasma GLP-1 concentration gastric half-emptying time (T50%)	—

Countries

Japan

Contacts

Public ContactHisayo Yokoyama

Osaka City University Graduate School of Medicine Environmental Physiology for Exercise

yokoyama@sports.osaka-cu.ac.jp06-6605-2947

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026