The effect of tolvaptan on renal function during intensive treatment in patients with congestive heart failure

The effect of tolvaptan on renal function during intensive treatment in patients with congestive heart failure - Renoprotective effect of tolvaptan in acute phase of patients with congestive heart failure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000014134

Enrollment

Registered

2014-05-31

Start date

2013-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

congestive heart failure

Interventions

(Standard treatment group) Daily 40 mg of intravenous furosemide (20 mg x 2), in addition to intravenous 0.025 gamma of carperitide and 200 mg of canrenoate potassium for 5 days. Renal functions and

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patient urgently hospitalized due to acute heart failure syndrome, or worsened chronic heart failure, with informed consent.

Exclusion criteria

Exclusion criteria: (i) Patient with malignant neoplasm who is expected that life expectancy is within 6 months (ii) Maintenance dialysis patient (iii) Patient with shock or pre shock vital signs on admission (iv) Patient younger than 30 years old (v) Inadequate patient judged by principal investigator

Design outcomes

Primary

Measure	Time frame
renal function	—

Secondary

Measure	Time frame
1. daily urine volume, fluid balance 2. plasma renin activity, plasma aldosterone concentration, catecholamines, BNP 3. systemic blood pressure 4. electrolytes 5. cardio-thoracic ratio 6. durations of NIPPV use, CCU and total hospitalization 7. in-hospital and long-term mortality	—

Countries

Japan

Contacts

Public ContactKentaro Jujo

Nishiarai Heart Center Hospital Department of Cardiology

juken1123@hotmail.co.jp+81358380730

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026