Comparative study on hypotensive effect by administration timing of L/N-type calcium channel blocker cilnidipine in chronic kidney disease patients

Comparative study on hypotensive effect by administration timing of L/N-type calcium channel blocker cilnidipine in chronic kidney disease patients - Hypotensive effect by administration timing of cilnidipine in chronic kidney disease patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000014108

Enrollment

Registered

2014-06-01

Start date

2014-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension with chronic kidney disease

Interventions

morning internal use group:patients are given 5-20mg of cilnidipine in morning. night internal use group:patients are given 5-20mg of cilnidipine at bedtime.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.CKD stage G1-5. 2.Hypertension:systolic blood pressure 130 mmHg or diastolic blood pressure 80 mmHg.

Exclusion criteria

Exclusion criteria: 1.Dialysis patients. 2.Clinical blood pressure is 180/100mmHg or more in antihypertensive treatment. 3.Patients already received cilnidipine. 4.Patients with a history of hypersensitivity to cilnidipine. 5.Pregnant women or women who are suspect of pregnancy. 6.Patients judged as inappropriate for the study.

Design outcomes

Primary

Measure	Time frame
Ambulatory blood pressure monitoring (ABPM)	—

Secondary

Measure	Time frame
1)BW, obesity, abdominal circumference. 2)Clinical blood pressure 3)Renal function 4)Cardiovascular function(Echocardiographic study, AI, ABI/baPWV), CAVI, Sympathetic nerve activity) 5)Blood examination 6)Lipid metabolism 7)Inflammatory marker	—

Countries

Japan

Contacts

Public ContactKouichi Tamura

Yokohama City University School of Medicine Department of Cardiorenal Medicine

tamukou@med.yokohama-cu.ac.jp045-787-2635

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026