Chronic kidney disease(CKD)
Conditions
Interventions
Postural change from the supine to the upright position.
Sponsors
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age ≥20 y 2. CKD based on K/DOQI criteria 3. documented informed concent 4. tolerance for 1.5 h-upright position
Exclusion criteria
Exclusion criteria: 1. previous treatment with ARB or diuretics 2 months before enrollment 2. presence or possibility of pregnancy 3. HbA1c >9.0 % 4. GOT >100, or GPT >85 5. endocrine hypertension 6. accelerated or malignant hypertension 7. serious conditions with congestive heart failure, coronary diseases, arrhythmia or systemic diseases 8. nephrotic syndrome (serum albumin <2.5 g/dl) 9. patients receiving hemodialysis therapy 10. any reason for ineligibility suggested by the attending doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relationship between the changes in resistive index in renal arteriole and natriuresis during the postural change from supine to the upright position. | — |
Secondary
| Measure | Time frame |
|---|---|
| Relationship between the POSTURAL changes in resistive index in renal arteriole and circadian BP rhythm and urinary excretion of angiotensinogen, as well as GFR | — |
Countries
Japan
Contacts
Public ContactToshiyuki Miura
Nagoya City University Graduate School of Medical Sciences Cardio-Renal Medicine and Hypertension
Outcome results
None listed