Examination of the procedures for suppressing endotracheal-induced adverse effects such as hemodynamic changes and sore throat during extubation.

Examination of the procedures for suppressing endotracheal-induced adverse effects such as hemodynamic changes and sore throat during extubation. - Examination of the procedures for suppressing adverse effects such as hemodynamic changes and sore throat during extubation.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000014026

Enrollment

Registered

2014-05-22

Start date

2014-05-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who undergo surgeries under general anesthesia

Interventions

An endotracheal tube cuff filled with alkalized lidocaine. An endotracheal tube cuff filled with saline.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who required a tracheal intubation.

Exclusion criteria

Exclusion criteria: Patients with anticipated difficult airway, patients who required a vasoactive agents after end of surgery, patients who were pretreated with beta-blockers.

Design outcomes

Primary

Measure	Time frame
Changes in blood pressure and heart rate before and after extubation.	—

Secondary

Measure	Time frame
The number of coughs before and after extubation and the degree of sore throat assessed by visual analogue scale and hoarseness after extubation.	—

Countries

Japan

Contacts

Public ContactKumiko Ishida

Shinshu University School of Medicine Department of Anesthesiology and Resuscitology

kumiko_m@shinshu-u.ac.jp0263372670

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026