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The effects of exercise on muscle strength and bone metabolism in maintenance hemodialysis patients -the contribution of myostatin, a peptide derived from skeletal muscle-

The effects of exercise on muscle strength and bone metabolism in maintenance hemodialysis patients -the contribution of myostatin, a peptide derived from skeletal muscle- - The contribution of myostatin to the effects of exercise on muscle strength and bone metabolism in maintenance hemodialysis patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000014005
Enrollment
20
Registered
2014-05-21
Start date
2014-06-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

maintenance hemodialysis patients

Interventions

intradialytic aerobic exercise and resistance training 3 sessions of 1 hour exercise per week 12 weeks no exercise

Sponsors

Osaka City University Graduate School of Medicine, Environmental Physiology for Exercise
Lead Sponsor
Jinshinkai, Shirasagi Hospital
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Maintenance hemodialysis patients at stable period with over 6 months passed from the initiation of the therapy. Patients receiving adequate hemodialysis (Kt/V is 1.2 and more) with stable blood pressure during the therapy, and the ability to walk over 50 m by themselves.

Exclusion criteria

Exclusion criteria: patients with diabetes, orthopedic disorders, abnormal findings such as ischemic change or severe arrhythmia on cardiopulmonary exercise test, heart failure on echocardiography (ejection fraction<50%). patients considered as inappropriate to participate in exercise by doctor.

Design outcomes

Primary

MeasureTime frame
serum myostatin level

Secondary

MeasureTime frame
bone mineral density of calcaneus, peak oxygen uptake, muscle mass of lower limb, muscle strength of quadriceps muscle

Countries

Japan

Contacts

Public ContactHisayo Yokoyama

Osaka City University Graduate School of Medicine Environmental Physiology for Exercise

yokoyama@sports.osaka-cu.ac.jp06-6605-2947

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026