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A prospective randomized study for improving the ovarian reserve by administration of granulocyte colony-stimulating factor (G-CSF).

A prospective randomized study for improving the ovarian reserve by administration of granulocyte colony-stimulating factor (G-CSF). - A study for improving the ovarian reserve with G-CSF.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000013956
Enrollment
226
Registered
2014-05-14
Start date
2014-05-19
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility treated by assisted reproductive technology.

Interventions

the control group who undergoes ART therapy without administration of G-CSF, and the G-CSF group who undergoes ART therapy after two months from administrations of G-CSF. And the outcomes of ART are c

Sponsors

Women's Clinic Jinno
Lead Sponsor
Inagi Municipal Hospital, Department of Obstetrics and Gynecology
Collaborator

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: The study include patients who satisfy all the following criteria; (1) age = or < 42 years, (2) to undergo the first or second attempt of ART therapy, (3) AMH < 2 ng/mL, and (4) day-3-FSH < 30 IU/mL.

Exclusion criteria

Exclusion criteria: Patients are excluded when they meet any of the following criteria; (1) to have a drug allergy or a dangerous allergic disease, (2) to have severe hepatic, renal, and/or heart diseases, and (3) to have the uterine infertility.

Design outcomes

Primary

MeasureTime frame
The rate of pregnancy

Secondary

MeasureTime frame
Follicular development, the numbers of retrieved oocytes, fertilized oocytes, and embryos, and hormones inculuding anti-Mullerian hormone (AMH)

Countries

Japan

Contacts

Public ContactMasao Jinno

Women's Clinic Jinno Department of Gynecology

mjinno@s9.dion.ne.jp042-480-3105

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026