Schizophrenia
Conditions
Interventions
Subjects are given antipsychotics with NAC (2000mg/day) as supplementation for 12 weeks. Clinical evaluations are conducted at baseline, 12- and 24-weeks.
Sponsors
Department of neuropsychiatry, St. Marianna University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inpatients and outpatients meeting criteria of schizophrenia are recruited from St. Marianna University School of Medicine Hospital.
Exclusion criteria
Exclusion criteria: i) comorbid central nervous system disorder ii) meeting the DSM-IV-TR criteria for current and/or past alcohol or other substance dependence or abuse iii) meeting the DSM-IV-TR criteria for mental retardation iv) taking tricyclic antidepressants v) treatment with electroconvulsive therapy within the 12 weeks preceding the study vi) treatment with lithium, valproic acid, carbamazepine vii) patients who were not voluntarily hospitalized viii) active expression of suicidal ideation ix) pregnancy or breast feeding x) inability to understand the study protocol or being judged as uncooperative by the rater.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PANSS (Positive And Negative Syndrome Scale), BACS-J(Brief Assessment of Cognition in Schizophrenia-Japanese version) | — |
Secondary
| Measure | Time frame |
|---|---|
| Magnetic resonance spectroscopy, Schizophrenia Cognition Rating Scale (SCoRS), UCSD Performance-based Skills Assessment-Brief (UPSA-B), Schizophrenia Quality of Life Scale-Japanese version (SQLS-J), Clinical Global Impression-Severity (CGI-S), Drug-Induced Extrapyramidal Symptoms Scale(DIEPSS), laboratory data | — |
Countries
Japan
Contacts
Public ContactNobumi Miyake
St. Marianna University School of Medicine Department of neuropsychiatry
Outcome results
None listed