Effects of N-acetylcysteine in subjects with at-risk mental state

Effects of N-acetylcysteine in subjects with at-risk mental state - Effects of N-acetylcysteine in subjects with at-risk mental state

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013736

Enrollment

Registered

2014-04-16

Start date

2012-10-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

At-risk mental state

Interventions

Control group with subthreshold psychosis are given normal treatment (supportive psychotherapy) including minimum use of the psychotropic drugs. Subjects with subthreshold psychosis are given normal t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Individuals meeting criteria of prodromal syndromes based on the structural interview for prodromal symptoms are recruited from St. Marianna University School of Medicine Hospital.

Exclusion criteria

Exclusion criteria: i) comorbid central nervous system disorder ii) meeting the DSM-IV-TR criteria for current and/or past alcohol or other substance dependence or abuse iii) meeting the DSM-IV-TR criteria for mental retardation iv) taking tricyclic antidepressants v) treatment with electroconvulsive therapy within the 12 weeks preceding the study vi) treatment with lithium, valproic acid, carbamazepine vii) patients who were not voluntarily hospitalized viii) active expression of suicidal ideation ix) pregnancy or breast feeding x) inability to understand the study protocol or being judged as uncooperative by the rater.

Design outcomes

Primary

Measure	Time frame
Changes in the Scale of Prodromal Symptoms (SOPS) Clinical evaluations: baseline, 12- and 24-weeks	—

Secondary

Measure	Time frame
Magnetic resonance spectroscopy, Brief Assessment of Cognition in Schizophrenia-Japanese language version (BACS-J), Schizophrenia Cognition Rating Scale (SCoRS), UCSD Performance-based Skills Assessment-Brief (UPSA-B), Schizophrenia Quality of Life Scale-Japanese version (SQLS-J), Drug-Induced Extrapyramidal Symptoms Scale(DIEPSS), laboratory tests	—

Countries

Japan

Contacts

Public ContactNobumi Miyake

St. Marianna University School of Medicine Department of neuropsychiatry

nobumiyake@marianna-u.ac.jp044-977-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026