acute decompensated heart failure
Conditions
Sponsors
Osaka General Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with left ventricular ejection fraction>=45% 2) Patients with at least one sign of congestion (edema, pulmonary congestion, pleural effusion, jugular venous distention, orthopnea) 3)Patients who received sufficient explanation, understood it and gave written consent based on their free will, before participating in this study
Exclusion criteria
Exclusion criteria: 1) Patients with hypernatremia (Na>147mEq/L) 2) Patients who do not need diuretic therapy because of dehydration 3) Patients with cardiovascular shock 4) Patients with anuria or patients under hemodialysis 5) Patients with acute coronary syndrome 6) Patients with insensitivity to thirst or difficulty in water intake 7) Patients who need mechanical circulatory assist device (IABP?PCPS) 8) Patients with malignant tumor 9) Patients who need temporary pacing because of bradycardia 10) Patients who were judged inappropriate by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H/M MIBG uptake ratio on the delayed images, Changes in washout rate of cardiac MIBG | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)blood biomarkers: vasopressin, three fractions of catecholamine, renin activity, aldosterone levels and serum osmolality 2)urinary biomarker: urinary albumin, urine beta2-microglobulin, urinary L-FABP and urine osmolality 3) Transthoracic echocardiography: LVEF, LVDd/Ds, E/e', LAD 4) Holter electrocardiogram: (TWA, HRV, HRT) 5) arrhythmia 6) cardiovascular event 7) acute kidney injury | — |
Countries
Japan
Contacts
Public ContactShunsuke Tamaki
Osaka General Medical Center Department of Cardiology
Outcome results
None listed