Establishment of the strategic prophylaxis for the deep vein thrombosis by the remote ischemic preconditioning.

Establishment of the strategic prophylaxis for the deep vein thrombosis by the remote ischemic preconditioning. - A single blind parallel group randomized trial about the efficacy and safety of the remote ischemic preconditioning for the development of deep vein thrombosis during total knee arthroplasty using the tourniquet.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013662

Enrollment

Registered

2014-04-08

Start date

2012-02-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

deep vein thrombosis

Interventions

Remote ischemic preconditioning induced by four 5-min cycles of upper limb ischemia and 5-min reperfusion using a blood-pressure cuff. Control group: Without remote ischemic preconditioning.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing unilateral total knee arthroplasty using the tourniquet. Written informed consent.

Exclusion criteria

Exclusion criteria: Anticoagulant therapy Heparin bridge Neuropathy of the superior limb Brachial edema RA Steroid therapy Ischemic heart disease Obesity BMI>30

Design outcomes

Primary

Measure	Time frame
Soluble fibrin monomer complex level D-Dimer level FDP level Plasminogen activity level	—

Secondary

Measure	Time frame
NF-kappa B level Plasma cytocine level (IL6, IL-1beta, IL-10, TNF-alpha) Safety (measured by incidence of adverse events and discontinuation rate due to adverse events)	—

Countries

Japan

Contacts

Public ContactKiyoshi Shakunaga

Toyama University Hospital Surgical Center

shaku@med.u-toyama.ac.jp076-434-7377

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026