PROSPECTIVE RANDOMIZED STUDY OF POLYDIMETHYLSILOXANE VS HYALURONIC ACID INJECTION FOR TREATMENT OF VESICOURETERAL REFLUX

PROSPECTIVE RANDOMIZED STUDY OF POLYDIMETHYLSILOXANE VS HYALURONIC ACID INJECTION FOR TREATMENT OF VESICOURETERAL REFLUX - Polydimethylsiloxane vs. hyaluronic acid comparison

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013649

Enrollment

250

Registered

2014-04-06

Start date

2005-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vesicoureteral reflux

Interventions

Endoscopic injection of polydimethylsiloxane (macro plastique) Endoscopic injection of hyaluronic acid (deflux)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Diagnosis of vesicoureteral reflux (VUR) using voiding cystouretrogram (VCUG),

Exclusion criteria

Exclusion criteria: Previous endoscopic treatment of VUR Active urinary tract infection at the time of injection Untreated bladder or bowel dysfunction Absence of follow-up imaging studies (US and/or VCUG) 3 months following the injection procedure

Design outcomes

Primary

Measure	Time frame
The primary outcome was surgical success (resolution vs. non resolution).	—

Secondary

Measure	Time frame
Secondary outcomes included the occurrence of adverse events.	—

Countries

North America

Contacts

Public ContactKatherine Moore

CHU de Quebec Pediatric Urology

katherine.moore.1@ulaval.ca418-654-2282

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026