Exploratory clinical study on effects to the blood flow and safety of transcutaneous application of carbon dioxide for fractured limbs

Exploratory clinical study on effects to the blood flow and safety of transcutaneous application of carbon dioxide for fractured limbs - Investigation of effects of transcutaneous application of carbon dioxide to fractured limbs

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013641

Enrollment

Registered

2014-07-01

Start date

2014-07-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fracture

Interventions

Transcutaneous application of carbon dioxide to fractured limbs

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with fracture of lower extremities Both acute phase and chronic phase of fracture Nonunion and bone defect Age over 15 Written informed consent Closed fracture and open fracture Conservative treatment and surgical treatment Any methods of surgical treatment

Exclusion criteria

Exclusion criteria: Pathological fracture Peripheral artery disease or ischemia in the fractured limb Skin disease in the fractured limb Infection in the fractured limb Inadequate condition both general and local No written informed consent Patients who are judged as contraindication with any reasons by the doctors in charge

Design outcomes

Primary

Measure	Time frame
Validation of accelerating effects to the blood flow of transcutaneous application of carbon dioxide for fractured limbs	—

Secondary

Measure	Time frame
Validation of safety of transcutaneous application of carbon dioxide for fractured limbs	—

Countries

Japan

Contacts

Public ContactTakahiro Niikura

Kobe University Graduate School of Medicine Orthopaedic Surgery

tniikura@med.kobe-u.ac.jp078-382-5985

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026