major depressive disorder, bipolar disorder
Conditions
Interventions
Low-frequency rTMS to the right dorsolateral prefrontal cortex or High-frequency rTMS to the left dorsolateral prefrontal cortex
Sponsors
Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
Okayama Psychiatric Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)DSM-IV-TR diagnosis of major depressive disorder (MDD) or bipolar disorder (BD) 2)Hamilton Scale for Depression 17-item score: 14 or more 3)Medication resistance(Insufficient clinical improvement of MDD from at least two antidepressant trials/ Insufficient clinical improvement of BD from lithium or lamotrigine and atypical antipsychotic treatment ) 4)Capability of informed consent 5)Aged 20 years old or more
Exclusion criteria
Exclusion criteria: 1)Other Axis I disorders 2)Axis II disorders 3)Seizure-inducing disease (brain tumor, head injury, etc.) 4)Neurologic disorder, organic brain disorder 5)History of seizure 6)Paroxysmal EEG abnormality 7)Pregnancy 8)Ferromagnetic material in head(except oral cavity) 9)Patients with a pacemaker 10)Active suicide idea 11)Stupor state 12)Previous treatment with electroconvulsive therapy within one month 13)Depressive patients related to physical diseases or drugs 14)Family members of researchers 15)Patients likely to change to another hospital within 6 months 16)Patients judged to be not appropriate for participation in this study by the physician 17) Patients who do not understand Japanese
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adherence to treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Beck Depression Inventry II(BDI-II) 2)Hamilton Depression Rating Scale (Ham-D) 17items 3)Montgomery Asberg Depression Scale (MADRS) 4)Frequency,Intensity, and Burden of Side Effects Rating (FIBSER) 5)Young Manic Rating Scale (YMRS) | — |
Countries
Japan
Contacts
Public ContactMasatoshi Inagaki
Okayama University Hospital Department of Neuropsychiatry
Outcome results
None listed