The effect ofgrepefruit juice on the patients with autoimmune diseases taking tacrolimus

The effect ofgrepefruit juice on the patients with autoimmune diseases taking tacrolimus - Effect of grapefruit juice with Tacrolimus

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013546

Enrollment

Registered

2014-03-31

Start date

2014-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rheumatoid arthritis, lupus nephritis, polymyositis/dermatomyositis with interstitial pneumonia, ulcerative colitis

Interventions

take a glass of grapefruit juice every day do not take grapefruit juice

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Autoimmune Disease Patients (with rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis / polymyositis, mixed connective tissue disease or ulcerative colitis) who are taking Tacrolimus with 3mg/day or more but the trough levels of serum tacrolimus concentration did not reach the minimal effecive range.

Exclusion criteria

Exclusion criteria: patients who do not satisfy the classification criteria of each disease and those who do not wish to perticipate in this clinical test.

Design outcomes

Primary

Measure	Time frame
Increase of tacrolimus blood concentration	—

Countries

Japan

Contacts

Public ContactHideki Tsuji

Kyoto University Department of Rheumatology and Clinical Immunology

htsuji@kuhp.kyoto-u.ac.jp075-751-3124

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026