hepatocellular carcinoma
Conditions
Interventions
Carbon-ion beam Total dose 60.0 GyE 4 fractions
Sponsors
SAGA HIMAT foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) The patient with single liver tumor diagnosed hepatocellular carcinoma pathollogically or clinically. 2) The tumor is measurable and the maximum diameter of the tumor is greater than 30mm. 3) cN0M0 (accrdiong to UICC(International Union Against Cancer) TMN classification of Malignant tumours 7th edition) 4) The Child-Pugh score of the patient is from 5 points to 8 points. 5) Perfomance status of the patient is from 0 to 2. 6) Life expectancy of the patients is longer than one year. 7) The patient is able to understand the explanation of the clinical trial and written informed concent is obtained.
Exclusion criteria
Exclusion criteria: 1) Patient have recieved any other therapies for hepatocellular carcinoma. 2) The alimentary tract is included in the planning target volume. 3) Patient with ascites. 4) Patient with hepatic encephalopathy. 5) Patient with sever paraesophageal varix or portal hypertention. 6) Patient with intractable esophageal or gastric varix. 7) Patients with any other active malignancies. 8) Patients with active and intractable infection at the same position where carbon-ion radiotherapy is planned.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-year overall survival 3-year cause-specific survival | — |
Secondary
| Measure | Time frame |
|---|---|
| 3-year local control rate Normal tissue reaction | — |
Countries
Japan
Contacts
Public ContactShingo Toyama
SAGA HIMAT foundation Ion Beam Therapy Center
Outcome results
None listed