Remodeling of neural networks in the treatment of geriatric depression using deep transcranial magnetic stimulation (DTMS): a preliminary study

Remodeling of neural networks in the treatment of geriatric depression using deep transcranial magnetic stimulation (DTMS): a preliminary study - Remodeling of neural networks in the treatment of geriatric depression using deep transcranial magnetic stimulation (DTMS): a preliminary study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013533

Enrollment

Registered

2014-04-01

Start date

2014-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder

Interventions

DTMS is administered using deep TMS (DTMS). Stimulation parameter is set at 120% MT with 18 Hz for 2 sec, with intervals of 20 sec (2700 pulses, 75 sessions, 27.5 min).

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: DSM-V diagnosis of major depressive disorder Aged 65-85 y/o HDRS 17 score greater than 18 Insufficient clinical benefit to 1-4 adequate medication trials in the current episode

Exclusion criteria

Exclusion criteria: Bipolar disorder, OCD, and PTSD Previous treatment with VNS and DBS Pregnancy Personal or close family history of seizure disorder Neurologic disorder, organic brain disease Substance or alcohol dependence Ferromagnetic material in body or close to head Severe metabolic disease, endocrine disease Active suicide idea Taking medications known to lower seizure threshold

Design outcomes

Primary

Measure	Time frame
HDRS 17	—

Secondary

Measure	Time frame
CGI, MMSE, stroop test, verbal fluency, trail making test, logical memory (WMS) fMRI, fNIRS, high-density EEG	—

Countries

Japan

Contacts

Public ContactShinsuke Kito

Kyorin University School of Medicine Department of Neuropsychiatry

kito@ks.kyorin-u.ac.jp+81-422-47-5511

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026