Patients (Major depressive disorder and bipolar II disorder) and healthy controls
Conditions
Interventions
Navigation-guided high-frequency rTMS site: left dorsolateral prefrontal cortex frequency: 10Hz (4sec. train, 26sec. interval) intensity: 100-120% resting motor threshold (RMT) number of pulses:
Sponsors
Graduate School of Medicine, Kyoto University
Rakunan hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients 1. Aged 20-75 years-old, male and female 2. Diagnosis of major depressive disorder or bipolar II disorder 3. Current diagnosis of major depressive episode 4. HAMD_17 >=14 or BDI >=20 5. resistent to medication (including medication intolerance) 6. Capability of informed consent Healthy controls 1. Aged 20-75 years-old, male and female without psychiatric disorder 2. No family history of major depressive disorder and bipolar disorder in their first relatives 3. Capability of informed consent
Exclusion criteria
Exclusion criteria: Patients and healthy controls 1. Implanted cardiac pacemaker 2. Surgical aneurysm clips 3. Neurostimulator 4. Implanted pumps 5. Metal fragments in body 6. Subjects who are contraindicated for the use of MRI [e.g. Tattoos, permanent eyeliner (if ink contains metallic specks)] 7. Diagnosis of neurological disorders (including epilepsy), substance dependence, or current serious medical illness (e.g. severe cardiac disease) 8. History of neurological disorders (including epilepsy), substance dependence, or head injury with loss of consciousness 9. Subjects with pregnancy or during lactation. 10. Subjects who are judged as unsuitable for participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| evaluate neural responses following rTMS using multi-modality of MRI and psychological tests. | — |
Countries
Japan
Contacts
Public ContactToshiya Murai
Graduate School of Medicine, Kyoto University Department of Psychiatry
Outcome results
None listed