Prospective observational study of the relationship between periodontal disease and lifestyle-related disease monitored by atherosclerosis-related biomarkers

Prospective observational study of the relationship between periodontal disease and lifestyle-related disease monitored by atherosclerosis-related biomarkers - Prospective observational study of the relationship between periodontal disease and lifestyle-related disease monitored by atherosclerosis-related biomarkers

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000013485

Enrollment

190

Registered

2014-03-23

Start date

2014-04-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Those who have given written informed consent on the use of their data for the study

Exclusion criteria

Exclusion criteria: Those who are considered not eligible for the study by attending doctors due to any medical reasons

Design outcomes

Primary

Measure	Time frame
Cross-sectional evaluation of the relationship between clinical parameters of periodontitis and incidence of lifestyle-related disease (diabetes mellitus, dyslipidemia, and hypertension) or atherosclerosis	—

Secondary

Measure	Time frame
1) Analysis of biomarkers and laboratory parameters related to diabetes mellitus, dyslipidemia, hypertension and atherosclerosis Serum markers hsCRP IL-6 TNF-alpha oxidized LDL Remnant small dense LDL HDL2 (HDL3) Adiponectin Myeloperoxidase (MPO) Podocalyxin Proproteinconvertase subtilisin/kexin type 9 Antibody against periodontopathic bacteria Urinary markers Megalin Podocalyxin Alpha1MG Beta2MG N-acetyl-beta-D-glucosaminidase (NAG) Albumin Neutrophil gelatinase-associated lipocalin (NGAL) L-type fatty acid binding protein (L-FABP) etc. 2) Intestinal flora Meta 16S rRNA gene analysis 3) PWV/ABI	—

Measure

Time frame

1) Analysis of biomarkers and laboratory parameters related to diabetes mellitus, dyslipidemia, hypertension and atherosclerosis Serum markers hsCRP IL-6 TNF-alpha oxidized LDL Remnant small dense LDL HDL2 (HDL3) Adiponectin Myeloperoxidase (MPO) Podocalyxin Proproteinconvertase subtilisin/kexin type 9 Antibody against periodontopathic bacteria Urinary markers Megalin Podocalyxin Alpha1MG Beta2MG N-acetyl-beta-D-glucosaminidase (NAG) Albumin Neutrophil gelatinase-associated lipocalin (NGAL) L-type fatty acid binding protein (L-FABP) etc. 2) Intestinal flora Meta 16S rRNA gene analysis 3) PWV/ABI

—

Countries

Japan

Contacts

Public ContactAkihiko Saito

Niigata University Graduate School of Medical and Dental Sciences Department of Applied Molecular Medicine

akisaito@med.niigata-u.ac.jp025-227-0915

Outcome results