Comparison of the night acid suppresion between Proton pump inhibitors in Helicobacter pylori negative healthy volunteers

Comparison of the night acid suppresion between Proton pump inhibitors in Helicobacter pylori negative healthy volunteers - IZUMO night pH study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013484

Enrollment

Registered

2014-12-30

Start date

2012-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux diseases (GERD)

Interventions

Esomeprazole 20mg once daily - wash out 7 days over - Rabeprazole 10mg once daily Rabeprazole 10mg once daily - wash out 7 days over - Esomeprazole 20mg once daily

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. healthy adults 2. BMI ranged from 19kg/m2 to 28kg/m2 3. without upper abdominal symptom 4. non smokers 5. without Helicobacter pylori

Exclusion criteria

Exclusion criteria: 1.with taking drugs affecting gastrointestinal motor function 2.with a history gastrectomy 3.complicated with severe cardiac, hematologic, renal, hepatic diseases or malignant tumor 4.possibility to be pregnant or pregnant women 5. subjects who are not eligible for participation judged by a doctor

Design outcomes

Primary

Measure	Time frame
evaluation of intra-gastric pH following single oral administrations of rabeprazole and esomeprazole on First day	—

Countries

Japan

Contacts

Public ContactKenji Furuta

Shimane University Faculty of Medicine Department of Internal Medicine II

kmyhy5@shimane-med.ac.jp0853-20-2190

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026