Pathophyisiology of nocturnal gastro-esophageal reflux events and the effects of sleep medications and proton pump inhibitor on nocturnal gastro-esophageal reflux events

Pathophyisiology of nocturnal gastro-esophageal reflux events and the effects of sleep medications and proton pump inhibitor on nocturnal gastro-esophageal reflux events - The effects of sleep medications and PPI on nocturnal GER events

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013480

Enrollment

Registered

2014-03-24

Start date

2014-03-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastro-esophageal reflux disease Sleep disorders Healthy subjects

Interventions

melatonin receptor agonist nonbenzodiazepine benzodiazepine proton pump inhibitor lactose

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. equall or older than 20-year-old 2. ability of writing concent 3. equall or more than 8 points in the FSSG questionnaire 4. presence of nocturnal reflux symptoms and presence of sleep disorders comfirmed by some questionnaires 5. having reflux esophagitis

Exclusion criteria

Exclusion criteria: 1. past history of surgery on upper GI tract 2. past history of surgery on nasal cavities 3. taking medications which may affect motility of upper GI tract 4. having neuromuscular diseases 5. haing GI motility disorders 6. cannot stop taking sleep medications 7. having diseases in which interventions cannot be apllied 8. pregnant or nurcing status 9. subjects who are not appropriate for this study

Design outcomes

Primary

Measure	Time frame
The number of nocturnal gastro-esophageal reflux events	—

Secondary

Measure	Time frame
The number of transient lower esophageal sphincter relaxation events The number of esophago-pahryngeal reflux events The number of arousals	—

Countries

Japan

Contacts

Public ContactShiko Kuribayashi

Gunma University Hospital Department of Gastroenterology and Hepatology

shikokuri@gunma-u.ac.jp027-220-8137

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026