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Clinical effect of early loading of eicosepentanoic acid for acute myocardial infarction: a prospective, open-labeled, randomized controlled clinical trial

Clinical effect of early loading of eicosepentanoic acid for acute myocardial infarction: a prospective, open-labeled, randomized controlled clinical trial - Clinical effect of early loading of eicosepentanoic acid for acute myocardial infarction

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000013472
Enrollment
100
Registered
2014-03-20
Start date
2010-10-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute myocardial infarction

Interventions

Patients received standard medication containing 2 mg/day of pitavastaitin as a control group. Patients received additional 1,800 mg/day of eicosapentaenoic acid as a EPA group.

Sponsors

Kagawa Prefectural Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Acute myocardial infarction patients treated with percutaneous coronary intervention within 24 hours of symptom onset were eligible to study population. Myocardial infarction was diagnosed according to the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction.

Exclusion criteria

Exclusion criteria: Exclusion criteria were cardiogenic shock, severe renal insufficiency requiring dialysis or continuous hemofiltration, cardiopulmonary arrest, emergent coronary artery bypass and failure of percutaneous coronary intervention

Design outcomes

Primary

MeasureTime frame
The primary end point was composite clinical outcomes, including ventricular arrhythmias, paroxysmal atrial fibrillation, re-infarction, stroke and death.

Secondary

MeasureTime frame
Secondary end-point was peak CRP value after PCI, MI size estimated by peak creatine kinase (CK), and left ventricular ejection fraction at 2 weeks after onset of acute MI.

Countries

Japan

Contacts

Public ContactMasayuki Doi

Kagawa Prefectural Central Hospital Cardiology

mdoimd@gmail.com087-811-3333

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026