Effect of weight reduction resulting from life style modification or bariatric surgery on pancreas fat accumulation and beta cell function in Japanse type 2 diabetes.

Effect of weight reduction resulting from life style modification or bariatric surgery on pancreas fat accumulation and beta cell function in Japanse type 2 diabetes. - Effect of weight reduction resulting from life style modification or bariatric surgery on pancreas fat accumulation and beta cell function in Japanse type 2 diabetes.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013396

Enrollment

Registered

2014-04-01

Start date

2014-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes, obesity

Interventions

life style modification bariatric surgery

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Insufficient effect of weight loss regardless of 6 month medical therapy. 2. Primary obesity patients aged from 20 to 65 years old. 3. Patients whose BMI levels were higher than 32 kg/m2. 4. Patients whose HbA1c levels were higher than 7.0%. 5. Patients who have diabetes and other obesity related disease; hypertension, liver dysfunction, dyslipidemia.

Exclusion criteria

Exclusion criteria: 1. Diabetes other than type 2 diabetes. 2. Patients who have a disease other than obesity related disease. 3. Patients who have a disease which is associated with the risk of surgery. 4. Patients who have mental disorder. 5. Excessive alcohol drinker. 6. Female patients who are willing to be pregnant and give a birth. 7. Patients who are not willing to lose weight. 8. Patients who are decided to be inadequete for participating this study by physitian in charge. 9. Patients who are decided to have a risk for baritric surgery by physitian in charge.

Design outcomes

Primary

Measure	Time frame
1. Insulin secretion before and after intervention. a. OGTT. b. Disposition Index (dual glucose clamp method). 2. Glucagon load test before and after intervention. 3. Pancreas fat before and after intervention. 4. Insulin secretion between two groups. a. OGTT. b. Disposition Index (dual glucose clamp method). 5. Glucagon load test between two groups. 6. Pancreas fat content between two groups. 7. Correlation between fat content and disposition index.	—

Measure

Time frame

1. Insulin secretion before and after intervention. a. OGTT. b. Disposition Index (dual glucose clamp method). 2. Glucagon load test before and after intervention. 3. Pancreas fat before and after intervention. 4. Insulin secretion between two groups. a. OGTT. b. Disposition Index (dual glucose clamp method). 5. Glucagon load test between two groups. 6. Pancreas fat content between two groups. 7. Correlation between fat content and disposition index.

—

Secondary

Measure	Time frame
1. Change of HbA1c levels before and after intervention. 2. Change of fasting glucagon levels before and after intervention. 3. Change of gastrointestinal hormones before and after intervention. 4. Comparison of HbA1c levels between two groups. 5. Comparison of fasting glucagon levels between two groups. 6. Comparison of gastrointestinal hormones between two groups.	—

Countries

Japan

Contacts

Public ContactMotoyuki Tamaki

The University of Tokushima Department of Endocrine and Metabolism

tamaki_m@tokushima-u.ac.jp+81-88-633-7587

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026