Chronic periodontitis
Conditions
Interventions
Test group 1. 15 patients 2. Two periodontal pockets are treated with a-PDT in twice at weekly intervals
Control group 1. 15 patients 2. Minocycline hydrochloride ointment are applied to 2 perio
Sponsors
Niigata University
Yoshino Dental Clinic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 30 years or older persons who obtained written informed consent. 2. Slight to severe chronic periodontitis patients 3. Possessed a minimum of 20 teeth 4. Having at least 2 teeth with probing pocket depth (PPD) 5-8 mm in a full-mouth.
Exclusion criteria
Exclusion criteria: 1. Persons who had received scaling and root planing within the previous 3 months 2. Persons who had taken systemic antibiotics or anti-inflammatory drugs within 3 months before experiment 3. Persons who had severe systemic diseases 4. Persons who is known or suspected hypersensitivity or intolerance to tetracyclines antibiotics, chlorhexidine and methylene blue. 5. Smoker 6. Persons who is suspected of having aggressive periodontitis 7. Persons who are pregnant or suspected to be pregnant. 8. Persons who have acatalasia, severe G6PD deficiency, Photosensitive epilepsy. 9. Persons who are judged to be unqualified for this study subjects by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of total bacteria and some periodontopathic bacteria in subgingival plaque | — |
Secondary
| Measure | Time frame |
|---|---|
| *Probing pocket depth *Bleeding on probing *Profile of bacterial flora in subgingival plaque *Biomarker level in gingival crevicular fluid | — |
Countries
Japan
Contacts
Public ContactToshiya Morozumi
Niigata University Medical & Dental Hospital
Outcome results
None listed