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A prospective, single-center randomised double-blinded parallel-group comparison study of the postoperative pain control efficacy of a sciatic nerve block versus combined local anaesthetic infiltration and continuous femoral nerve block after total knee arthroplasty

A prospective, single-center randomised double-blinded parallel-group comparison study of the postoperative pain control efficacy of a sciatic nerve block versus combined local anaesthetic infiltration and continuous femoral nerve block after total knee arthroplasty - Postoperative pain control efficacy of a sciatic nerve block versus combined local anaesthetic infiltration and continuous femoral nerve block after total knee arthroplasty

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000013364
Enrollment
34
Registered
2014-03-07
Start date
2012-10-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Degenerative arthritis

Interventions

Subjects were administered a 20-ml bolus injection of 0.375% ropivacaine for a femoral nerve block and catheter were inserted for a continuous femoral nerve block after the insertion of a laryngeal ai
3 upon exiting the operating room and at 3, 6, 12, and 24 h after that time or at any other time they requested an analgesic with an NRS greater than 3. The participants had received an explanation th
3), 15 mg of pentazocine was injected intramuscularly. Nurses in the operating room and on the ward who were blinded to the group allocations recorded the NRS. Subjects were moved to a lateral re

Sponsors

Saitama City Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria:  TKA for degenerative arthritis  American Society of Anesthesiologists physical status, 1–3  Weight, 40–99 kg  Fully understood the study contents from oral and written descriptions

Exclusion criteria

Exclusion criteria:  Bilateral TKA  Regular narcotic users  Allergy to any study drug  Neuromuscular disease  Sensory disturbances of the leg  Severe diabetes  Heart failure (AHA >3)  Renal impairment with an estimated glomerular filtration rate of <60 mL min-1 1.73 m-2,  Liver dysfunction (Child–Pugh > B)  Impossible to assess using the numeric rating scale (NRS)

Design outcomes

Primary

MeasureTime frame
Comparison of changes in Numerical Rating Scale (NRS) between local anaesthetic infiltration and sciatic nerve block at five time points; on exiting the operating room and 3, 6, 12, 24 hour later.—

Countries

Japan

Contacts

Public ContactTomoyuki Sato

Saitama City Hospital Department of Intensive Care

tomoyukisatoh@seagreen.ocn.ne.jp048-873-4111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026