Hypertension
Conditions
Interventions
Increased Ca channel blocker regimen group Up to 12 weeks: Irbesarten100mg/amlodipine 10mg From 12 weeks to 24 weeks: antihypertensive drugs other than ARBs, Ca channel blockers, and diuretics are a
Sponsors
Asahikawa Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with essential hypertension, who have been previously treated with ARBs and Ca channel blockers (Irbesartan 100mg/Amlodipine 5mg or usual dosage of ARBs/Amlodipine 5mg) and whose blood pressure has not been adequately controlled with the treatment ( SBP>=140mmHg and /or DBP>=90mmHg). 2) Age more than 20 and less than 85 years 3) Outpatients 4) Patients understand the study procedures and agree to participate in the study by giving written informed consent prior to the start of the study.
Exclusion criteria
Exclusion criteria: 1) Patients with secondary hypertension 2) Patients with a history of severe renal disease: serum creatinine>2.0 mg/dl 3) Patients with critical liver damage (AST or ALT>100 IU/l) 4) Patients with a history of adverse effects to ARBs 5) Bilateral renal artery stenosis 6) Patients with hyperkalemia >=5.5 mEq/L 7) Patients with pregnancy or breast-feeding 8) Patients with a poor prognosis such as a malignant tumor 9) Patients who are considered not to be eligible for the study by the investigator due to medical reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic/Diastolic blood pressure change after a 12 week treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure change (home blood pressure monitoring in the morning and at night) Change in the ambulatory blood pressure (ABPM) The rate of achieving the target blood pressure Change in the laboratory data Systolic/Diastolic blood pressure change after a 24 week treatment The rate of continued treatment and the compliance of the treatment at 24 weeks | — |
Countries
Japan
Contacts
Public ContactNobuyuki Sato
Asahikawa Medical University Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine
Outcome results
None listed