Blood pressure-oriented versus blood flow-oriented circulatory management for preventing intraventricular hemorrhage in VLBW infants during first 7 days: a randomized trial

Blood pressure-oriented versus blood flow-oriented circulatory management for preventing intraventricular hemorrhage in VLBW infants during first 7 days: a randomized trial - Blood pressure-oriented versus blood flow-oriented circulatory management for preventing intraventricular hemorrhage in VLBW infants

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013296

Enrollment

440

Registered

2014-03-31

Start date

2014-05-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiovascular failure in very low birth weight infants

Interventions

blood pressure-oriented group: administering circulatory agent aiming to keep blood pressure above the number of gestational age blood flow-oriented group: administering circulatory agent aiming to

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Very low birth weight infant (less than 1500g of birth weight)

Exclusion criteria

Exclusion criteria: chromosomal anomaly major anomaly congenital heart disease severe asphyxia Gestationalage less than 22 weeks

Design outcomes

Secondary

Measure	Time frame
1. mortality during neonatal period 2. mortality at 1 year of age 3. incidence proportion of periventricular leukomalacia 4. incidence proportion of necrotizing enterocolitis 5. incidence proportion of retinopathy of prematurity 6. proportion of infants who received any kinds of circulatory support 7. proportion of infants who could not achieve the goal of therapies (blood pressure or blood flow)	—

Primary

Measure	Time frame
incidence proportion of intraventricular hemorrhage	—

Countries

Japan

Contacts

Public ContactAkio Ishiguro

Saitama Medical Center, Saitama Medical University Department of Pediatrics

akio-i@k4.dion.ne.jp+81-049-228-3890

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026