Major depressive disorder (Monopolar depression) and bipolar disorder(Bipolar I disorder and bipolar II disorder)
Conditions
Interventions
fMRI neurofeedback Connectivity-based neurofeedback using a 3T fMRI apparatus
Navigation-guided high-frequency rTMS TMS coil: air-cooled figure-of-eight coil site: left dorsolateral prefrontal
Sponsors
Kyoto University Graduate School of Medicine
Advanced Telecommunications Research Institute International(ATR)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. DSM-IV-TR diagnosis of major depressive disorder or bipolar disorder(BPI or II) 2. Current diagnosis of major depressive episode 3. Normal visual acuity 4. Aged 20-75 years-old, outpatients, self-sustained ADL 5. Capability of informed consent
Exclusion criteria
Exclusion criteria: 1. Implanted cardiac pacemaker 2. Surgical aneurysm clips 3. Neurostimulator 4. Implanted pumps 5. Metal fragments in body/eyes 6. Tattoos or permanent eyeliner (if ink contains metallic specks) 7. Treatment history of ECT 8. Diagnosis of neurological disorders (including epilepsy), substance dependence, or significant cardiac disease 9. History of neurological disorders (including epilepsy), substance dependence, or head injury with loss of consciousness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Hamilton Depression Rating Scale (Ham-D) 17items and 24items 2) Beck Depression Inventry II (BDI-II) 3) Self-rating Depression Scale (SDS) 4) rTMS side effects questionnaire, which was translated in Japanese from original version of Center for Noninvasive Brain Stimulation, Harvard Medical School.: evaluated every rTMS session | — |
Secondary
| Measure | Time frame |
|---|---|
| 5) State-Trait Anxiety Inventory (STAI) 6) Bipolar Spectrum Diganostic Scale (BSDS) 7) Neuropsychological Tests (Emotional "Face-word" Stroop Task, Four-armed Bandit Task) | — |
Countries
Japan
Contacts
Public ContactHidehiko Takahashi
Kyoto University Graduate School of Medicine Department of Psychiatry
Outcome results
None listed