locally-advanced and metastatic breast cancer
Conditions
Interventions
RESAIC(redistributed subclavian arterial infusion chemotherapy)
Sponsors
Japan Interventional Radiology in Oncology Study Group (JIVROSG)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients with symptomatic, locally-inoperable or locally-recurrent invasive breast cancer 2)[Primary breast cancer] Prior treatment with local radiotheraly and more than three prior chemotherapyincluding an anthracycline and a taxane OR [Recurrent breast cancer] Prior treatment with local radiotheraly and more than four prior chemotherapy including an anthracycline and a taxane (including neoadjuvant/adjuvant chemotherapy) 3) Cumulative dose of anthracycline (doxorubicin) within 300mg/m2 4) Measurable lesion in the breast or on the chestwall 5) PS (ECOG) 0-2 6) Adequate organ function 7) More than 2 weeks from prior treatment
Exclusion criteria
Exclusion criteria: a)History of non-breast malignancies within the 5 years prior to study entry b)Symptomatic breast metastasis c)Concurrent serious diseases that may interfere with planned treatment d) Stenosis of subclavian artery by contrast-enhanced CT e) bilateral breast cancer or multiple lesions within the region f) Pregnant or lactating women g) Patient unfeasible for ambulatory chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| local response rate | — |
Countries
Japan
Contacts
Public ContactMiyuki Sone
National Cancer Center Hospital Department of Radiology
Outcome results
None listed