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Prospective multicenter study on efficacy of the mediastinal and para-aortic lymph node dissection for esophagogastric junction cancer.

Prospective multicenter study on efficacy of the mediastinal and para-aortic lymph node dissection for esophagogastric junction cancer. - Prospective study on efficacy of lymph node dissection for EGJ cancer.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000013205
Enrollment
360
Registered
2014-02-20
Start date
2014-02-21
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophagogastric junction cancer

Interventions

Thorough mediastinal and para-aortic lymph node dissection via a transthoracic approach, or lower mediastinal and para-aortic lymph node dissection via a transhiatal approach

Sponsors

Working Group of Japanese Gastric Cancer Association and Japan Esophageal Society
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) An epicenter of tumor locates within 2cm of the esophagogastric junction. 2) Histologicall proven adenocarcinoma, squamous cell carcinoma, or adenosquamous carcinoma. 3) cT2-T4. 4) Resectable. 5) Age of 20 years or older. 6) ECOG performance status of 0 or 1. 7) Adequate organ function as follows: WBC >=3,000/mm3, Hemoglobin >=8.0 g/dL, Platelet >=75,000/mm3, Total bilirubin <=3.0 mg/dL, Creatinine <=2.0 mg/dL. 8) Written informed consent.

Exclusion criteria

Exclusion criteria: 1) Prior history of gastrectomy. 2) Cannot perform the surgery prerescribed in the protocol.

Design outcomes

Primary

MeasureTime frame
Metastasis rates of the respective lymph nodes—

Secondary

MeasureTime frame
Recurrence-free survival, Overall survival, Therapeutic value index calculated by multiplication of the metastasis rate by the 5-year overall survival rate in patients with metastasis in the respective nodes, R0 resection rate, Postoperative complications, Sites of recurrence—

Countries

Japan

Contacts

Public ContactYukinori Kurokawa

Osaka University Graduate School of Medicine Department of Gastroenterological Surgery

ykurokawa@gesurg.med.osaka-u.ac.jp06-6879-3251

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026