A study on the effect of proton pump inhibitors on intra-gastric pH in healthy adults: comparison of rabeprazole and esomeprazole

A study on the effect of proton pump inhibitors on intra-gastric pH in healthy adults: comparison of rabeprazole and esomeprazole - Comparison of rabeprazole and esomeprazole

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013165

Enrollment

Registered

2014-02-19

Start date

2014-02-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux diseases (GERD)

Interventions

Esomeprazole 20mg twice daily for 5 days-over 6 days-Rabeprazole 20mg twice daily for 5 days- over 6 days- Rabeprazole 10mg twice daily for 5 days Rabeprazole 10mg twice daily for 5 days- over 6 days-

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. healthy adults 2. subjects with written informed concent 3. subjects without Helicobacter pylori infection 4. subjects with CYP2C19 extensive metabolizer 5. subjects with BMI ranged from 18.5kg/m2 to 25.0kg/m2

Exclusion criteria

Exclusion criteria: 1. subjects with taking drugs affecting gastrointestinal motor function 2. subjects with upper abdominal symptom 3. subjects with a history gastrectomy 4. subjects who cannot stop smoking during the study period 5. subjects who are not eligible for participation judged by a doctor

Design outcomes

Primary

Measure	Time frame
evaluation of intra-gastric pH after administration of Rabeprazole or Esomeprazole for 5 days	—

Countries

Japan

Contacts

Public ContactNorihisa Ishimura

Shimane University Faculty of Medicine Department of Internal Medicine II

ishimura@med.shimane-u.ac.jp0853-20-2190

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026