Effects of monounsaturated fatty acid and sitagliptin on insulin secretion and endothelial function (EMSIE study)

Effects of monounsaturated fatty acid and sitagliptin on insulin secretion and endothelial function (EMSIE study) - EMSIE study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000013023

Enrollment

Registered

2014-02-14

Start date

2013-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteer and patients with type 2 diabetes mellitus

Interventions

carbohydrate 75 g (300kcal) carbohydrate 75 g (300kcal) + butter (240kcal) carbohydrate 75 g (300kcal) + oliveoil 27 g (240kcal) carbohydrate 75 g (300kcal) + sitagliptin 50mg

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy volunteer and type 2 diabetes mellitus, who agree to the study protocol

Exclusion criteria

Exclusion criteria: 1. Medication affecting study results 2. Poor diabetes control 3. Severe infection, operation and trauma before 3 months 4. Severe liver or kidney dysfunction 5. Other inappropriate causes

Design outcomes

Primary

Measure	Time frame
Blood pressure, glucose, insulin, lipids, GIP, GLP-1, adipocytokines and %change of flow- and nitroglycerine-mediated dilatation before and after meal tolerance test	—

Countries

Japan

Contacts

Public ContactMichio Shimabukuro

The University of Tokushima Graduate School of Health Biosciences Department of Cardio-Diabetes Medicine

mshimabukuro-ur@umin.ac.jp080-633-7859

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026